| Pos. | Jugador | Goles | Equipo |
|---|---|---|---|
| 1 | Daniel Güiza | 26 | Mallorca |
| 2 | Luis Fabiano | 24 | Sevilla |
| 3 | Sergio Agüero | 18 | Atlético de Madrid |
| 3 | Kahveci Nihat | 18 | Villarreal |
| 3 | González Raúl | 18 | Real Madrid |
| 6 | Diego Forlán | 16 | Atlético de Madrid |
| 6 | Ricardo Oliveira | 16 | Zaragoza |
| 6 | David Villa | 16 | Valencia |
| 9 | Diego Milito | 15 | Zaragoza |
| 9 | Samuel Eto'o | 15 | Barcelona |
| 11 | Frederic Kanouté | 14 | Sevilla |
| 11 | Ruud Van Nistelrooy | 14 | Real Madrid |
| 13 | Álvaro Negredo | 13 | U.D Almería |
| 13 | Joseba Llorente | 13 | Valladolid |
| 15 | Luis García | 12 | Espanyol |
| 15 | Luis Schmidt Edú | 12 | Betis |
| 15 | Juan Arango | 12 | Mallorca |
| 18 | Fernando Llorente | 11 | Athletic Club |
| 18 | Thierry Henry | 11 | Barcelona |